Cardinals vs Cubs Free Picks & Tips | Boyd Dominates as Hot Cubs Continue Divisional Surge

Cardinals vs Cubs Free Picks & Tips | Boyd Dominates as Hot Cubs Continue Divisional Surge

Game Details

Sunday Night Showdown: Cardinals vs Cubs Prediction, Odds & Best Bets for July 6

Date/Time: July 6, 2025 — 6:10 PM ET

Location: Wrigley Field, Chicago, Illinois

TV: ESPN

Betting Odds

Moneyline: Cardinals +171 / Cubs -208

Over/Under Total: 7.5 runs

Early money heavily favoring the Cubs with 68% of tickets backing the home favorite.

Game Overview

The Cardinals and Cubs split the first two games of this pivotal NL Central series, with St. Louis exploding for five runs in the eighth inning to steal Saturday's contest 8-6. Chicago has dominated at home this season (29-16) and sits atop the division, while the Cardinals are struggling on the road (22-25) but remain competitive in the playoff race. The pitching matchup strongly favors Chicago, with All-Star candidate Matthew Boyd (8-3, 2.65 ERA) facing the struggling Erick Fedde (3-8, 4.56 ERA) in what could be the deciding factor in this rubber match.

Key Matchups & Analysis

  • Boyd's Dominance at Home
    Matthew Boyd has been nearly untouchable at Wrigley Field this season, posting a 1.98 ERA in eight home starts. He's allowed two or fewer runs in seven consecutive outings overall with a stellar 1.66 ERA during this stretch, making him one of the hottest pitchers in baseball right now.
  • Fedde's Road Struggles
    Erick Fedde has been ineffective away from Busch Stadium, posting a 5.82 ERA in road starts this season. His strikeout-to-walk ratio (57:41) indicates command issues that could be exploited by a disciplined Cubs lineup that ranks second in the NL in team batting average.
  • Cubs' Power Surge
    Chicago's offense has been red-hot, with Michael Busch homering in back-to-back games against Cardinals pitching. The Cubs are averaging 5.6 runs per game during their last 10 contests, while Seiya Suzuki continues to lead the team with 24 home runs and ranks among MLB leaders in RBIs.
  • Bullpen Comparison
    The Cardinals have the advantage in the closer role with Ryan Helsley (17 saves), but the Cubs' bullpen has been more reliable overall in high-leverage situations. Chicago's relief corps features several reliable arms including Brad Keller (14 holds) and Caleb Thielbar, giving them late-game stability if Boyd doesn't go deep.

Prediction

I’m strongly backing the Chicago Cubs on the moneyline (-208) in this Sunday night divisional showdown. The pitching matchup creates a significant mismatch that can’t be overlooked. Boyd has been sensational over his last seven starts, while Fedde continues to struggle with command issues. Wrigley Field may be a pitcher-friendly park (0.898 run factor), but the Cubs’ lineup has shown they can produce runs in bunches, especially against struggling right-handers.

The Cardinals’ offense has been inconsistent on the road, and they’re hitting just .216 over their last 10 games. Brendan Donovan has been their lone bright spot offensively, but he’ll face a tough test against Boyd, who has limited left-handed hitters to a .198 average this season. With temperature expected in the mid-80s and moderate humidity, conditions favor Boyd’s breaking pitches having sharp movement.

For those looking for better value, I recommend the Cubs run line (-1.5 at +135), as seven of their last nine victories have been by multiple runs. This is a statement game for Chicago as they look to cement their position atop the NL Central heading into the All-Star break, and Boyd has the stuff to shut down the Cardinals’ struggling offense.

Best Bets

Final Score Prediction: Cubs 5, Cardinals 2

Betting Pick: Cubs -208

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